Job Description

Job Family:
Scientific Research & Analysis

Travel Required:
None

Clearance Required:
Ability to Obtain Public Trust

What You Will Do:
We are currently searching for Bioinformatics Scientist to provide bioinformatics support to advance the institute research programs, with a primary focus on single cell and spatial omics data analysis. This is a full-time, on-site opportunity in Durham, NC.

• Collaborate with scientists to design, analyze, manage and interpret all types of data.

• Conduct analyses on NextGen sequencing data including data derived in ChIP-Seq,RNA-Seq, miRNA-Seq and other experimental models.

• Work with an interdisciplinary team to apply computational data analysis approaches to make biological discoveries.

• Conduct analysis and interpretation on data from genomic platforms including expression, exon, tiling, promoter and others array types.

• Work independently with research groups to develop, implement, and refine analytical pipeline for single cell data analysis.

• Develop, optimize, and maintain bioinformatics pipelines, scripts, and computational tools for large-scale data analysis (e.g., NGS, scRNA-seq, multi-omics).

• Perform advanced statistical and computational analyses to interpret complex datasets and derive actionable biological insights.

• Collaborate with scientists and researchers to design experiments, select appropriate analytical approaches, and troubleshoot methodologies.

• Integrate and analyze diverse genomic and multi-omic datasets, including sequencing and public data sources.

• Install, configure, and support scientific software across computing platforms; ensure reproducibility through standardized workflows and documentation.

• Generate reports, visualizations, and presentations to communicate findings to scientific and technical audiences.

• Evaluate and implement new bioinformatics tools, statistical methods, and computational approaches based on current literature and research needs.

• Provide training and technical guidance to staff on bioinformatics tools, pipelines, and data analysis techniques.

• Maintain detailed documentation, laboratory records, and progress reports; present findings at meetings and contribute to publications.

• Support interdisciplinary collaborations and contribute to advancing research objectives aligned with organizational mission.
• Must be able to obtain and maintain a Federal or DoD "public trust"; candidates must receive approved adjudication prior to onboarding with Guidehouse. Candidates with an active public trust or suitability are preferred.

What You Will Need:

• Master's degree in bioinformatics, biostatistics, computational biology or biological/life science.

• At least TWO (2) years of data analysis experience.

• Advanced proficiency in disciplines such as statistical modeling, machine learning, and integrative analysis to extract biologically meaningful insights from complex cellular systems.

• Knowledgeable with a variety of next gen sequencing techniques.

• Experience working with analytical tools, software and platforms such as, but not limited to, R, Python, MATLAB, SAS, PERL, Java, Shell, Bash, Seurat / Scanpy, Linux, Unix, Bioconductor, Cloud computing, High-Performance Computing (HPC).
• Must be able to obtain and maintain a Federal or DoD "public trust"; candidates must obtain approved adjudication of their public trust prior to onboarding with Guidehouse. Candidates with an active public trust or suitability are preferred

What Would Be Nice To Have:

• PhD preferred

• Strong verbal and written communication skills

• Familiar with multiple next gen sequencing techniques

• Ability to collaborate closely with investigators and multidisciplinary teams to design analytical strategies, ensure data quality, interpret results, and translate findings into actionable scientific conclusions.

What We Offer:

Guidehouse offers a comprehensive, total rewards package that includes competitive compensation and a flexible benefits package that reflects our commitment to creating a diverse and supportive workplace.

Benefits include:

• Medical, Rx, Dental & Vision Insurance
• Personal and Family Sick Time & Company Paid Holidays
• Parental Leave
• 401(k) Retirement Plan
• Group Term Life and Travel Assistance
• Voluntary Life and AD&D Insurance
• Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts
• Transit and Parking Commuter Benefits
• Short-Term & Long-Term Disability
• Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities
• Employee Referral Program
• Corporate Sponsored Events & Community Outreach
• Care.com annual membership
• Employee Assistance Program
• Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.)
• Position may be eligible for a discretionary variable incentive bonus

About Guidehouse

Guidehouse is an Equal Opportunity Employer-Protected Veterans, Individuals with Disabilities or any other basis protected by law, ordinance, or regulation.

Guidehouse will consider for employment qualified applicants with criminal histories in a manner consistent with the requirements of applicable law or ordinance including the Fair Chance Ordinance of Los Angeles and San Francisco.

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